Analysis of the Inhibition of Mammalian Carboxylesterases by Novel Fluorobenzoins and Fluorobenzils

We have synthesized and assessed the ability of symmetrical fluorobenzoins and fluorobenzils to inhibit mammalian carboxylesterases (CE). The majority of the latter were excellent inhibitors of CEs however unexpectedly, the fluorobenzoins were very good enzyme inhibitors. Positive correlations were...

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Hauptverfasser: Hicks, Latorya D., Hyatt, Janice L, Moak, Teri, Edwards, Carol C., Tsurkan, Lyudmila, Wierdl, Monika, Ferreira, Antonio, Wadkins, Randy M., Potter, Philip M.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2007
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1995442/
https://ncbi.nlm.nih.gov/pubmed/17399985
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmc.2007.03.012
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