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Modifications of human carboxylesterase for improved prodrug activation
BACKGROUND: Carboxylesterases (CE) are ubiquitous enzymes responsible for the hydrolysis of numerous clinically useful drugs. Since ester moieties are frequently included in molecules to improve their water solubility and bioavailability, de facto they become substrates for CEs. OBJECTIVE: In this r...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2008
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2556898/ https://ncbi.nlm.nih.gov/pubmed/18721110 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1517/17425255.4.9.1153 |
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