The interaction of buthionine sulphoximide (BSO) and the topoisomerase I inhibitor CPT-11.

Buthionine sulphoximide (BSO)-induced depletion of glutathione (GSH) was found to be associated with an increased sensitivity to CPT-11 (topoisomerase I-reactive agent) in V79 hamster lung fibroblast cells. When V79 cells were exposed to 2.5 mM BSO for 28 h beginning 4 h prior to a 24 h coincubation...

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Autores principales: Sawyer, T. E., Bonner, J. A.
Formato: Artigo
Lenguaje:Inglês
Publicado: Nature Publishing Group 1996
Materias:
Research Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC2150031/
https://ncbi.nlm.nih.gov/pubmed/8763860
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