Pharmacological targeting of NF-κB potentiates the effect of the topoisomerase inhibitor CPT-11 on colon cancer cells

NF-κB interferes with the effect of most anti-cancer drugs through induction of anti-apoptotic genes. Targeting NF-κB is therefore expected to potentiate conventional treatments in adjuvant strategies. Here we used a pharmacological inhibitor of the IKK2 kinase (AS602868) to block NF-κB activation....

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Detalhes bibliográficos
Main Authors: Lagadec, P, Griessinger, E, Nawrot, M P, Fenouille, N, Colosetti, P, Imbert, V, Mari, M, Hofman, P, Czerucka, D, Rousseau, D, Berard, E, Dreano, M, Peyron, J F
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2008
Assuntos:
Translational Therapeutics
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2361441/
https://ncbi.nlm.nih.gov/pubmed/18182997
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjc.6604082
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