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Intestinal glucuronidation protects against chemotherapy-induced toxicity by irinotecan (CPT-11)
Camptothecin (CPT)-11 (irinotecan) has been used widely for cancer treatment, particularly metastatic colorectal cancer. However, up to 40% of treated patients suffer from severe late diarrhea, which prevents CPT-11 dose intensification and efficacy. CPT-11 is a prodrug that is hydrolyzed by hepatic...
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| Main Authors: | , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
2013
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3839688/ https://ncbi.nlm.nih.gov/pubmed/24191041 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1319123110 |
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