Intestinal glucuronidation protects against chemotherapy-induced toxicity by irinotecan (CPT-11)

Camptothecin (CPT)-11 (irinotecan) has been used widely for cancer treatment, particularly metastatic colorectal cancer. However, up to 40% of treated patients suffer from severe late diarrhea, which prevents CPT-11 dose intensification and efficacy. CPT-11 is a prodrug that is hydrolyzed by hepatic...

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מידע ביבליוגרפי
Main Authors: Chen, Shujuan, Yueh, Mei-Fei, Bigo, Cyril, Barbier, Olivier, Wang, Kepeng, Karin, Michael, Nguyen, Nghia, Tukey, Robert H.
פורמט: Artigo
שפה:Inglês
יצא לאור: National Academy of Sciences 2013
נושאים:
Biological Sciences
גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC3839688/
https://ncbi.nlm.nih.gov/pubmed/24191041
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1319123110
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