Impediments to Enhancement of CPT-11 Anticancer Activity by E. coli Directed Beta-Glucuronidase Therapy

CPT-11 is a camptothecin analog used for the clinical treatment of colorectal adenocarcinoma. CPT-11 is converted into the therapeutic anti-cancer agent SN-38 by liver enzymes and can be further metabolized to a non-toxic glucuronide SN-38G, resulting in low SN-38 but high SN-38G concentrations in t...

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Udgivet i:PLoS One
Main Authors: Hsieh, Yuan-Ting, Chen, Kai-Chuan, Cheng, Chiu-Min, Cheng, Tian-Lu, Tao, Mi-Hua, Roffler, Steve R.
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2015
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4331512/
https://ncbi.nlm.nih.gov/pubmed/25688562
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0118028
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