Molecular Insights into Microbial β-Glucuronidase Inhibition to Abrogate CPT-11 Toxicity

Bacterial β-glucuronidases expressed by the symbiotic intestinal microbiota appear to play important roles in drug-induced epithelial cell toxicity in the gastrointestinal (GI) tract. For the anticancer drug CPT-11 (irinotecan) and the nonsteroidal anti-inflammatory drug diclofenac, it has been show...

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Detaylı Bibliyografya
Asıl Yazarlar: Roberts, Adam B., Wallace, Bret D., Venkatesh, Madhu Kumar, Mani, Sridhar, Redinbo, Matthew R.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: The American Society for Pharmacology and Experimental Therapeutics 2013
Konular:
Articles
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC3716326/
https://ncbi.nlm.nih.gov/pubmed/23690068
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/mol.113.085852
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