Targeting Regorafenib-induced Toxicity through Inhibition of Gut Microbial β-Glucuronidases

Regorafenib (Stivarga) is an oral small molecule kinase inhibitor used to treat metastatic colorectal cancer, hepatocellular carcinomas, and gastrointestinal stromal tumors. Diarrhea is one of the most frequently observed adverse reactions associated with regorafenib. This toxicity may arise from th...

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Udgivet i:ACS Chem Biol
Main Authors: Ervin, Samantha M., Hanley, Ronan P., Lim, Lauren, Walton, William G., Pearce, Kenneth H., Bhatt, Aadra P., James, Lindsey I., Redinbo, Matthew R.
Format: Artigo
Sprog:Inglês
Udgivet: 2019
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7254866/
https://ncbi.nlm.nih.gov/pubmed/31663730
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acschembio.9b00663
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