Structure, function, and inhibition of drug reactivating human gut microbial β-glucuronidases

Bacterial β-glucuronidase (GUS) enzymes cause drug toxicity by reversing Phase II glucuronidation in the gastrointestinal tract. While many human gut microbial GUS enzymes have been examined with model glucuronide substrates like p-nitrophenol-β-D-glucuronide (pNPG), the GUS orthologs that are most...

Descripció completa

Guardat en:
Dades bibliogràfiques
Publicat a:Sci Rep
Autors principals: Biernat, Kristen A., Pellock, Samuel J., Bhatt, Aadra P., Bivins, Marissa M., Walton, William G., Tran, Bich Ngoc T., Wei, Lianjie, Snider, Michael C., Cesmat, Andrew P., Tripathy, Ashutosh, Erie, Dorothy A., Redinbo, Matthew R.
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group UK 2019
Matèries:
Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6351562/
https://ncbi.nlm.nih.gov/pubmed/30696850
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-018-36069-w
Etiquetes: Afegir etiqueta
Sense etiquetes, Sigues el primer a etiquetar aquest registre!

Ítems similars