Structure, function, and inhibition of drug reactivating human gut microbial β-glucuronidases

Bacterial β-glucuronidase (GUS) enzymes cause drug toxicity by reversing Phase II glucuronidation in the gastrointestinal tract. While many human gut microbial GUS enzymes have been examined with model glucuronide substrates like p-nitrophenol-β-D-glucuronide (pNPG), the GUS orthologs that are most...

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Détails bibliographiques
Publié dans:Sci Rep
Auteurs principaux: Biernat, Kristen A., Pellock, Samuel J., Bhatt, Aadra P., Bivins, Marissa M., Walton, William G., Tran, Bich Ngoc T., Wei, Lianjie, Snider, Michael C., Cesmat, Andrew P., Tripathy, Ashutosh, Erie, Dorothy A., Redinbo, Matthew R.
Format: Artigo
Langue:Inglês
Publié: Nature Publishing Group UK 2019
Sujets:
Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6351562/
https://ncbi.nlm.nih.gov/pubmed/30696850
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-018-36069-w
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