Structure, function, and inhibition of drug reactivating human gut microbial β-glucuronidases

Bacterial β-glucuronidase (GUS) enzymes cause drug toxicity by reversing Phase II glucuronidation in the gastrointestinal tract. While many human gut microbial GUS enzymes have been examined with model glucuronide substrates like p-nitrophenol-β-D-glucuronide (pNPG), the GUS orthologs that are most...

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Bibliografische gegevens
Gepubliceerd in:Sci Rep
Hoofdauteurs: Biernat, Kristen A., Pellock, Samuel J., Bhatt, Aadra P., Bivins, Marissa M., Walton, William G., Tran, Bich Ngoc T., Wei, Lianjie, Snider, Michael C., Cesmat, Andrew P., Tripathy, Ashutosh, Erie, Dorothy A., Redinbo, Matthew R.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Nature Publishing Group UK 2019
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Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6351562/
https://ncbi.nlm.nih.gov/pubmed/30696850
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-018-36069-w
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