Gut Microbial β-Glucuronidase Inhibition via Catalytic Cycle Interception

[Image: see text] Microbial β-glucuronidases (GUSs) cause severe gut toxicities that limit the efficacy of cancer drugs and other therapeutics. Selective inhibitors of bacterial GUS have been shown to alleviate these side effects. Using structural and chemical biology, mass spectrometry, and cell-ba...

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Publicat a:ACS Cent Sci
Autors principals: Pellock, Samuel J., Creekmore, Benjamin C., Walton, William G., Mehta, Naimee, Biernat, Kristen A., Cesmat, Andrew P., Ariyarathna, Yamuna, Dunn, Zachary D., Li, Bo, Jin, Jian, James, Lindsey I., Redinbo, Matthew R.
Format: Artigo
Idioma:Inglês
Publicat: American Chemical Society 2018
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6062831/
https://ncbi.nlm.nih.gov/pubmed/30062115
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acscentsci.8b00239
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