Gut Microbial β-Glucuronidase Inhibition via Catalytic Cycle Interception

[Image: see text] Microbial β-glucuronidases (GUSs) cause severe gut toxicities that limit the efficacy of cancer drugs and other therapeutics. Selective inhibitors of bacterial GUS have been shown to alleviate these side effects. Using structural and chemical biology, mass spectrometry, and cell-ba...

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Detalhes bibliográficos
Publicado no:ACS Cent Sci
Main Authors: Pellock, Samuel J., Creekmore, Benjamin C., Walton, William G., Mehta, Naimee, Biernat, Kristen A., Cesmat, Andrew P., Ariyarathna, Yamuna, Dunn, Zachary D., Li, Bo, Jin, Jian, James, Lindsey I., Redinbo, Matthew R.
Formato: Artigo
Idioma:Inglês
Publicado em: American Chemical Society 2018
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6062831/
https://ncbi.nlm.nih.gov/pubmed/30062115
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acscentsci.8b00239
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