Targeting Regorafenib-induced Toxicity through Inhibition of Gut Microbial β-Glucuronidases

Regorafenib (Stivarga) is an oral small molecule kinase inhibitor used to treat metastatic colorectal cancer, hepatocellular carcinomas, and gastrointestinal stromal tumors. Diarrhea is one of the most frequently observed adverse reactions associated with regorafenib. This toxicity may arise from th...

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Detalhes bibliográficos
Publicado no:ACS Chem Biol
Main Authors: Ervin, Samantha M., Hanley, Ronan P., Lim, Lauren, Walton, William G., Pearce, Kenneth H., Bhatt, Aadra P., James, Lindsey I., Redinbo, Matthew R.
Formato: Artigo
Idioma:Inglês
Publicado em: 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7254866/
https://ncbi.nlm.nih.gov/pubmed/31663730
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acschembio.9b00663
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