Piperlongumine and its analogs down-regulate expression of c-Met in renal cell carcinoma

The c-Met protein, a transmembrane receptor tyrosine kinase, is the product of a proto-oncogene. Its only known ligand, hepatocyte growth factor (HGF), regulates cell growth, motility, migration, invasion, proliferation, and angiogenesis. The aberrant expression of c-Met is often associated with poo...

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Bibliographic Details
Published in:Cancer Biol Ther
Main Authors: Golovine, Konstantin, Makhov, Peter, Naito, Sei, Raiyani, Henish, Tomaszewski, Jeffrey, Mehrazin, Reza, Tulin, Alexei, Kutikov, Alexander, Uzzo, Robert G, Kolenko, Vladimir M
Format: Artigo
Language:Inglês
Published: Taylor & Francis 2015
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Research Paper
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4623021/
https://ncbi.nlm.nih.gov/pubmed/25801713
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/15384047.2015.1026511
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