Piperlongumine promotes autophagy via inhibition of Akt/mTOR signalling and mediates cancer cell death

BACKGROUND: The Akt/mammalian target of rapamycin (mTOR) signalling pathway serves as a critical regulator of cellular growth, proliferation and survival. Akt aberrant activation has been implicated in carcinogenesis and anticancer therapy resistance. Piperlongumine (PL), a natural alkaloid present...

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Detalhes bibliográficos
Main Authors: Makhov, P, Golovine, K, Teper, E, Kutikov, A, Mehrazin, R, Corcoran, A, Tulin, A, Uzzo, R G, Kolenko, V M
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2014
Assuntos:
Translational Therapeutics
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3929888/
https://ncbi.nlm.nih.gov/pubmed/24434432
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/bjc.2013.810
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