LDL cholesterol counteracts the antitumour effect of tyrosine kinase inhibitors against renal cell carcinoma

BACKGROUND: Treatment with tyrosine kinase inhibitors (TKIs) significantly improves survival of patients with renal cell carcinoma (RCC). However, about one-quarter of the RCC patients are primarily refractory to treatment with TKIs. METHODS: We examined viability of RCC and endothelial cells treate...

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Detalhes bibliográficos
Publicado no:Br J Cancer
Main Authors: Naito, Sei, Makhov, Peter, Astsaturov, Igor, Golovine, Konstantin, Tulin, Alexei, Kutikov, Alexander, Uzzo, Robert G, Kolenko, Vladimir M
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2017
Assuntos:
Translational Therapeutics
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5418451/
https://ncbi.nlm.nih.gov/pubmed/28350788
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/bjc.2017.77
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