Generation of Naivetropic Induced Pluripotent Stem Cells from Parkinson's Disease Patients for High-Efficiency Genetic Manipulation and Disease Modeling

The lack of robust Parkinson's disease (PD) phenotype in parkin knockout rodents and the identification of defective dopaminergic (DA) neurotransmission in midbrain DA neurons derived from induced pluripotent stem cells (iPSC) of PD patients with parkin mutations demonstrate the utility of pati...

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Dettagli Bibliografici
Pubblicato in:Stem Cells Dev
Autori principali: Hu, Zhixing, Pu, Jiali, Jiang, Houbo, Zhong, Ping, Qiu, Jingxin, Li, Feng, Wang, Xiaomin, Zhang, Baorong, Yan, Zhen, Feng, Jian
Natura: Artigo
Lingua:Inglês
Pubblicazione: Mary Ann Liebert, Inc. 2015
Soggetti:
Original Research Reports
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4620536/
https://ncbi.nlm.nih.gov/pubmed/26218671
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1089/scd.2015.0079
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