Generation of Naivetropic Induced Pluripotent Stem Cells from Parkinson's Disease Patients for High-Efficiency Genetic Manipulation and Disease Modeling

The lack of robust Parkinson's disease (PD) phenotype in parkin knockout rodents and the identification of defective dopaminergic (DA) neurotransmission in midbrain DA neurons derived from induced pluripotent stem cells (iPSC) of PD patients with parkin mutations demonstrate the utility of pati...

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Bibliographische Detailangaben
Veröffentlicht in:Stem Cells Dev
Hauptverfasser: Hu, Zhixing, Pu, Jiali, Jiang, Houbo, Zhong, Ping, Qiu, Jingxin, Li, Feng, Wang, Xiaomin, Zhang, Baorong, Yan, Zhen, Feng, Jian
Format: Artigo
Sprache:Inglês
Veröffentlicht: Mary Ann Liebert, Inc. 2015
Schlagworte:
Original Research Reports
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4620536/
https://ncbi.nlm.nih.gov/pubmed/26218671
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1089/scd.2015.0079
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