Chronic Activation of the Renin-Angiotensin System Induces Lung Fibrosis

Pulmonary fibrosis is a serious lung disorder that can lead to respiratory failure. Here we show that transgenic mice expressing active renin from the liver (RenTgMK) developed progressive pulmonary fibrosis leading to impaired pulmonary function. Histological analyses revealed a marked increase in...

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Bibliographic Details
Published in:	Sci Rep
Main Authors:	Wang, Jiaolong, Chen, Li, Chen, Bohao, Meliton, Angelo, Liu, Shu Q., Shi, Yongyan, Liu, Tianjing, Deb, Dilip K., Solway, Julian, Chun Li, Yan
Format:	Artigo
Language:	Inglês
Published:	Nature Publishing Group 2015
Subjects:	Article
Online Access:	https://ncbi.nlm.nih.gov/pmc/articles/PMC4616037/ https://ncbi.nlm.nih.gov/pubmed/26494430 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep15561
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Chronic Activation of the Renin-Angiotensin System Induces Lung Fibrosis

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