Activation of the Renin-Angiotensin System Promotes Colitis Development

The renin-angiotensin system (RAS) plays pathogenic roles in renal and cardiovascular disorders, but whether it is involved in colitis is unclear. Here we show that RenTgMK mice that overexpress active renin from the liver developed more severe colitis than wild-type controls. More than 50% RenTgMK...

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Publicat a:Sci Rep
Autors principals: Shi, Yongyan, Liu, Tianjing, He, Lei, Dougherty, Urszula, Chen, Li, Adhikari, Sarbani, Alpert, Lindsay, Zhou, Guolin, Liu, Weicheng, Wang, Jiaolong, Deb, Dilip K., Hart, John, Liu, Shu Q., Kwon, John, Pekow, Joel, Rubin, David T., Zhao, Qun, Bissonnette, Marc, Li, Yan Chun
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group 2016
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4897651/
https://ncbi.nlm.nih.gov/pubmed/27271344
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep27552
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