Activation of the Renin-Angiotensin System Promotes Colitis Development

The renin-angiotensin system (RAS) plays pathogenic roles in renal and cardiovascular disorders, but whether it is involved in colitis is unclear. Here we show that RenTgMK mice that overexpress active renin from the liver developed more severe colitis than wild-type controls. More than 50% RenTgMK...

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Pubblicato in:Sci Rep
Autori principali: Shi, Yongyan, Liu, Tianjing, He, Lei, Dougherty, Urszula, Chen, Li, Adhikari, Sarbani, Alpert, Lindsay, Zhou, Guolin, Liu, Weicheng, Wang, Jiaolong, Deb, Dilip K., Hart, John, Liu, Shu Q., Kwon, John, Pekow, Joel, Rubin, David T., Zhao, Qun, Bissonnette, Marc, Li, Yan Chun
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group 2016
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4897651/
https://ncbi.nlm.nih.gov/pubmed/27271344
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep27552
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