Chronic Activation of the Renin-Angiotensin System Induces Lung Fibrosis

Pulmonary fibrosis is a serious lung disorder that can lead to respiratory failure. Here we show that transgenic mice expressing active renin from the liver (RenTgMK) developed progressive pulmonary fibrosis leading to impaired pulmonary function. Histological analyses revealed a marked increase in...

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Udgivet i:Sci Rep
Main Authors: Wang, Jiaolong, Chen, Li, Chen, Bohao, Meliton, Angelo, Liu, Shu Q., Shi, Yongyan, Liu, Tianjing, Deb, Dilip K., Solway, Julian, Chun Li, Yan
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group 2015
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4616037/
https://ncbi.nlm.nih.gov/pubmed/26494430
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep15561
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