A small molecule FAK kinase inhibitor, GSK2256098, inhibits growth and survival of pancreatic ductal adenocarcinoma cells

Focal adhesion kinase (FAK) hyperactivation is common in pancreatic ductal adenocarcinoma (PDAC). A small molecule, GSK2256098 (GlaxoSmithKline), has been developed to inhibit FAK activity through targeting the phosphorylation site of FAK, tyrosine (Y) 397. We sought to determine whether GSK2256098...

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Pubblicato in:Cell Cycle
Autori principali: Zhang, Jianliang, He, Di-Hua, Zajac-Kaye, Maria, Hochwald, Steven N
Natura: Artigo
Lingua:Inglês
Pubblicazione: Taylor & Francis 2014
Soggetti:
Reports
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4615113/
https://ncbi.nlm.nih.gov/pubmed/25486573
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/15384101.2014.949550
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