A small molecule FAK kinase inhibitor, GSK2256098, inhibits growth and survival of pancreatic ductal adenocarcinoma cells

Focal adhesion kinase (FAK) hyperactivation is common in pancreatic ductal adenocarcinoma (PDAC). A small molecule, GSK2256098 (GlaxoSmithKline), has been developed to inhibit FAK activity through targeting the phosphorylation site of FAK, tyrosine (Y) 397. We sought to determine whether GSK2256098...

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Bibliografiske detaljer
Udgivet i:Cell Cycle
Main Authors: Zhang, Jianliang, He, Di-Hua, Zajac-Kaye, Maria, Hochwald, Steven N
Format: Artigo
Sprog:Inglês
Udgivet: Taylor & Francis 2014
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Reports
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4615113/
https://ncbi.nlm.nih.gov/pubmed/25486573
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/15384101.2014.949550
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