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Evidence for a CDK4-dependent checkpoint in a conditional model of cellular senescence

Cellular senescence, the stable cell cycle arrest elicited by various forms of stress, is an important facet of tumor suppression. Although much is known about the key players in the implementation of senescence, including the pRb and p53 axes and the cyclin dependent kinase inhibitors p16(INK4a) an...

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Vydáno v:Cell Cycle
Hlavní autoři: Brookes, Sharon, Gagrica, Sladjana, Sanij, Elaine, Rowe, Janice, Gregory, Fiona J, Hara, Eiji, Peters, Gordon
Médium: Artigo
Jazyk:Inglês
Vydáno: Taylor & Francis 2015
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4613988/
https://ncbi.nlm.nih.gov/pubmed/25695870
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/15384101.2015.1010866
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