Biallelic Mutations in p16(INK4a) Confer Resistance to Ras- and Ets-Induced Senescence in Human Diploid Fibroblasts

The INK4a/ARF tumor suppressor locus is implicated in the senescence-like growth arrest provoked by oncogenic Ras in primary cells. INK4a and ARF are distinct proteins encoded by transcripts in which a shared exon is decoded in alternative reading frames. Here we analyze dermal fibroblasts (designat...

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Detalhes bibliográficos
Main Authors: Huot, Thomas J., Rowe, Janice, Harland, Mark, Drayton, Sarah, Brookes, Sharon, Gooptu, Chandra, Purkis, Patricia, Fried, Mike, Bataille, Veronique, Hara, Eiji, Newton-Bishop, Julia, Peters, Gordon
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2002
Assuntos:
Cell Growth and Development
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC134058/
https://ncbi.nlm.nih.gov/pubmed/12417717
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.22.23.8135-8143.2002
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