Biallelic Mutations in p16(INK4a) Confer Resistance to Ras- and Ets-Induced Senescence in Human Diploid Fibroblasts

The INK4a/ARF tumor suppressor locus is implicated in the senescence-like growth arrest provoked by oncogenic Ras in primary cells. INK4a and ARF are distinct proteins encoded by transcripts in which a shared exon is decoded in alternative reading frames. Here we analyze dermal fibroblasts (designat...

Полное описание

Сохранить в:
Библиографические подробности
Главные авторы: Huot, Thomas J., Rowe, Janice, Harland, Mark, Drayton, Sarah, Brookes, Sharon, Gooptu, Chandra, Purkis, Patricia, Fried, Mike, Bataille, Veronique, Hara, Eiji, Newton-Bishop, Julia, Peters, Gordon
Формат: Artigo
Язык:Inglês
Опубликовано: American Society for Microbiology 2002
Предметы:
Cell Growth and Development
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC134058/
https://ncbi.nlm.nih.gov/pubmed/12417717
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.22.23.8135-8143.2002
Метки: Добавить метку
Нет меток, Требуется 1-ая метка записи!

Схожие документы