CDK4 and CDK6 Delay Senescence by Kinase-Dependent and p16(INK4a)-Independent Mechanisms

Replicative senescence of human diploid fibroblasts (HDFs) is largely implemented by the cyclin-dependent kinase (CDK) inhibitors p16(INK4a) and p21(CIP1). Their accumulation results in a loss of CDK2 activity, and cells arrest with the retinoblastoma protein (pRb) in its hypophosphorylated state. I...

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Detaylı Bibliyografya
Asıl Yazarlar: Ruas, Margarida, Gregory, Fiona, Jones, Rebecca, Poolman, Robert, Starborg, Maria, Rowe, Janice, Brookes, Sharon, Peters, Gordon
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: American Society for Microbiology 2007
Konular:
Articles
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC1900050/
https://ncbi.nlm.nih.gov/pubmed/17420273
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.02286-06
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