Cargando...

CDK4 and CDK6 Delay Senescence by Kinase-Dependent and p16(INK4a)-Independent Mechanisms

Replicative senescence of human diploid fibroblasts (HDFs) is largely implemented by the cyclin-dependent kinase (CDK) inhibitors p16(INK4a) and p21(CIP1). Their accumulation results in a loss of CDK2 activity, and cells arrest with the retinoblastoma protein (pRb) in its hypophosphorylated state. I...

Descrición completa

Gardado en:
Detalles Bibliográficos
Main Authors: Ruas, Margarida, Gregory, Fiona, Jones, Rebecca, Poolman, Robert, Starborg, Maria, Rowe, Janice, Brookes, Sharon, Peters, Gordon
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Microbiology 2007
Assuntos:
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC1900050/
https://ncbi.nlm.nih.gov/pubmed/17420273
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.02286-06
Tags: Engadir etiqueta
Sen Etiquetas, Sexa o primeiro en etiquetar este rexistro!