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CDK4 and CDK6 Delay Senescence by Kinase-Dependent and p16(INK4a)-Independent Mechanisms
Replicative senescence of human diploid fibroblasts (HDFs) is largely implemented by the cyclin-dependent kinase (CDK) inhibitors p16(INK4a) and p21(CIP1). Their accumulation results in a loss of CDK2 activity, and cells arrest with the retinoblastoma protein (pRb) in its hypophosphorylated state. I...
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| Autores principales: | , , , , , , , |
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| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
American Society for Microbiology
2007
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| Materias: | |
| Acceso en línea: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1900050/ https://ncbi.nlm.nih.gov/pubmed/17420273 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.02286-06 |
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