Induced Expression of p16(INK4a) Inhibits Both CDK4- and CDK2-Associated Kinase Activity by Reassortment of Cyclin-CDK-Inhibitor Complexes

To investigate the mode of action of the p16(INK4a) tumor suppressor protein, we have established U2-OS cells in which the expression of p16(INK4a) can be regulated by addition or removal of isopropyl-β-d-thiogalactopyranoside. As expected, induction of p16(INK4a) results in a G(1) cell cycle arrest...

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Detalhes bibliográficos

Publicado no:	Mol Cell Biol
Principais autores:	McConnell, Beth B., Gregory, Fiona J., Stott, Francesca J., Hara, Eiji, Peters, Gordon
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Taylor & Francis 1999
Assuntos:	Cell Growth and Development
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC83991/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10022885/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/mcb.19.3.1981
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