Control of Spermatogenesis in Mice by the Cyclin D-Dependent Kinase Inhibitors p18(Ink4c) and p19(Ink4d)

Male mice lacking both the Ink4c and Ink4d genes, which encode two inhibitors of D-type cyclin-dependent kinases (Cdks), are infertile, whereas female fecundity is unaffected. Both p18(Ink4c) and p19(Ink4d) are expressed in the seminiferous tubules of postnatal wild-type mice, being largely confined...

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Main Authors: Zindy, Frederique, den Besten, Willem, Chen, Bo, Rehg, Jerold E., Latres, Esther, Barbacid, Mariano, Pollard, Jeffrey W., Sherr, Charles J., Cohen, Paula E., Roussel, Martine F.
Format: Artigo
Jezik:Inglês
Izdano: American Society for Microbiology 2001
Teme:
Cell Growth and Development
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC86968/
https://ncbi.nlm.nih.gov/pubmed/11287627
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.21.9.3244-3255.2001
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