INK4d-Deficient Mice Are Fertile Despite Testicular Atrophy

The INK4 family of cyclin-dependent kinase (CDK) inhibitors includes four 15- to 19-kDa polypeptides (p16(INK4a), p15(INK4b), p18(INK4c), and p19(INK4d)) that bind to CDK4 and CDK6. By disrupting cyclin D-dependent holoenzymes, INK4 proteins prevent phosphorylation of the retinoblastoma protein and...

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Main Authors: Zindy, Frederique, van Deursen, Jan, Grosveld, Gerard, Sherr, Charles J., Roussel, Martine F.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology 2000
Fag:
Mammalian Genetic Models with Minimal or Complex Phenotypes
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC85092/
https://ncbi.nlm.nih.gov/pubmed/10594039
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