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Assembly of cyclin D-dependent kinase and titration of p27(Kip1) regulated by mitogen-activated protein kinase kinase (MEK1)

A constitutively active form of mitogen-activated protein kinase kinase (MEK1) was synthesized under control of a zinc-inducible promoter in NIH 3T3 fibroblasts. Zinc treatment of serum-starved cells activated extracellular signal-regulated protein kinases (ERKs) and induced expression of cyclin D1....

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Detalhes bibliográficos
Main Authors: Cheng, Mangeng, Sexl, Veronika, Sherr, Charles J., Roussel, Martine F.
Formato: Artigo
Idioma:Inglês
Publicado em: The National Academy of Sciences 1998
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC18683/
https://ncbi.nlm.nih.gov/pubmed/9448290
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