Cyclin D-CDK Subunit Arrangement Is Dependent on the Availability of Competing INK4 and p21 Class Inhibitors

The D-type cyclins and their major kinase partners CDK4 and CDK6 regulate G(0)-G(1)-S progression by contributing to the phosphorylation and inactivation of the retinoblastoma gene product, pRB. Assembly of active cyclin D-CDK complexes in response to mitogenic signals is negatively regulated by INK...

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Detalhes bibliográficos

Publicado no:	Mol Cell Biol
Principais autores:	Parry, David, Mahony, Daniel, Wills, Ken, Lees, Emma
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Taylor & Francis 1999
Assuntos:	Cell Growth and Development
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC83971/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10022865/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/mcb.19.3.1775
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