Cyclin D-CDK Subunit Arrangement Is Dependent on the Availability of Competing INK4 and p21 Class Inhibitors
The D-type cyclins and their major kinase partners CDK4 and CDK6 regulate G(0)-G(1)-S progression by contributing to the phosphorylation and inactivation of the retinoblastoma gene product, pRB. Assembly of active cyclin D-CDK complexes in response to mitogenic signals is negatively regulated by INK...
Guardat en:
| Publicat a: | Mol Cell Biol |
|---|---|
| Autors principals: | , , , |
| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
Taylor & Francis
1999
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC83971/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10022865/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/mcb.19.3.1775 |
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