CDK inhibitors p18(INK4c) and p27(Kip1) mediate two separate pathways to collaboratively suppress pituitary tumorigenesis

INK4 and CIP/KIP are two distinct families of cyclin-dependent kinase (CDK) inhibitors implicated in mediating a wide range of cell growth control signals. We have created p18(INK4c)-deficient mice. These mice develop gigantism and widespread organomegaly. The pituitary gland, spleen, and thymus are...

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Detalhes bibliográficos
Main Authors: Franklin, David S., Godfrey, Virginia L., Lee, Hayyoung, Kovalev, Grigoriy I., Schoonhoven, Robert, Chen-Kiang, Selina, Su, Lishan, Xiong, Yue
Formato: Artigo
Idioma:Inglês
Publicado em: Cold Spring Harbor Laboratory Press 1998
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC317173/
https://ncbi.nlm.nih.gov/pubmed/9744866
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