CDK inhibitors p18(INK4c) and p27(Kip1) mediate two separate pathways to collaboratively suppress pituitary tumorigenesis

INK4 and CIP/KIP are two distinct families of cyclin-dependent kinase (CDK) inhibitors implicated in mediating a wide range of cell growth control signals. We have created p18(INK4c)-deficient mice. These mice develop gigantism and widespread organomegaly. The pituitary gland, spleen, and thymus are...

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Dades bibliogràfiques

Publicat a:	Genes Dev
Autors principals:	Franklin, David S., Godfrey, Virginia L., Lee, Hayyoung, Kovalev, Grigoriy I., Schoonhoven, Robert, Chen-Kiang, Selina, Su, Lishan, Xiong, Yue
Format:	Artigo
Idioma:	Inglês
Publicat:	Cold Spring Harbor Laboratory Press 1998
Matèries:	Research Paper
Accés en línia:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC317173/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9744866/ https://ncbi.nlm.nih.govhttps://doi.org/10.1101/gad.12.18.2899
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