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Requirement of Cyclin E-Cdk2 Inhibition in p16(INK4a)-Mediated Growth Suppression

Loss-of-function mutations of p16(INK4a) have been identified in a large number of human tumors. An established biochemical function of p16 is its ability to specifically inhibit cyclin D-dependent kinases in vitro, and this inhibition is believed to be the cause of the p16-mediated G(1) cell cycle...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Jiang, Hong, Chou, Hubert S., Zhu, Liang
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Microbiology 1998
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC109114/
https://ncbi.nlm.nih.gov/pubmed/9710613
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