Requirement of Cyclin E-Cdk2 Inhibition in p16(INK4a)-Mediated Growth Suppression

Loss-of-function mutations of p16(INK4a) have been identified in a large number of human tumors. An established biochemical function of p16 is its ability to specifically inhibit cyclin D-dependent kinases in vitro, and this inhibition is believed to be the cause of the p16-mediated G(1) cell cycle...

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Pubblicato in:	Mol Cell Biol
Autori principali:	Jiang, Hong, Chou, Hubert S., Zhu, Liang
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	Taylor & Francis 1998
Soggetti:	Cell Growth and Development
Accesso online:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC109114/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9710613/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/mcb.18.9.5284
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