Induced Expression of p16(INK4a) Inhibits Both CDK4- and CDK2-Associated Kinase Activity by Reassortment of Cyclin-CDK-Inhibitor Complexes
To investigate the mode of action of the p16(INK4a) tumor suppressor protein, we have established U2-OS cells in which the expression of p16(INK4a) can be regulated by addition or removal of isopropyl-β-d-thiogalactopyranoside. As expected, induction of p16(INK4a) results in a G(1) cell cycle arrest...
Kaydedildi:
| Yayımlandı: | Mol Cell Biol |
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| Asıl Yazarlar: | , , , , |
| Materyal Türü: | Artigo |
| Dil: | Inglês |
| Baskı/Yayın Bilgisi: |
Taylor & Francis
1999
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| Konular: | |
| Online Erişim: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC83991/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10022885/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/mcb.19.3.1981 |
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