Induced Expression of p16(INK4a) Inhibits Both CDK4- and CDK2-Associated Kinase Activity by Reassortment of Cyclin-CDK-Inhibitor Complexes

To investigate the mode of action of the p16(INK4a) tumor suppressor protein, we have established U2-OS cells in which the expression of p16(INK4a) can be regulated by addition or removal of isopropyl-β-d-thiogalactopyranoside. As expected, induction of p16(INK4a) results in a G(1) cell cycle arrest...

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Bibliographic Details
Main Authors: McConnell, Beth B., Gregory, Fiona J., Stott, Francesca J., Hara, Eiji, Peters, Gordon
Format: Artigo
Language:Inglês
Published: American Society for Microbiology 1999
Subjects:
Cell Growth and Development
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC83991/
https://ncbi.nlm.nih.gov/pubmed/10022885
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