INK4a-deficient human diploid fibroblasts are resistant to RAS-induced senescence

The CDKN2A tumour suppressor locus encodes two distinct proteins, p16(INK4a) and p14(ARF), both of which have been implicated in replicative senescence, the state of permanent growth arrest provoked in somatic cells by aberrant proliferative signals or by cumulative population doublings in culture....

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Main Authors: Brookes, Sharon, Rowe, Janice, Ruas, Margarida, Llanos, Susana, Clark, Paula A., Lomax, Martine, James, Marion C., Vatcheva, Radost, Bates, Stewart, Vousden, Karen H., Parry, David, Gruis, Nelleke, Smit, Nico, Bergman, Wilma, Peters, Gordon
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2002
Assuntos:
Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC126048/
https://ncbi.nlm.nih.gov/pubmed/12065407
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/emboj/cdf289
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados