A First-in-Human Phase I Study of MORAb-004, a Monoclonal Antibody to Endosialin in Patients with Advanced Solid Tumors

PURPOSE: Endosialin (TEM-1, CD248) is a protein expressed on the surface of activated mesenchymal cells, including certain subsets of tumors. Preclinical models suppressing endosialin function have shown antitumor activity. A humanized monoclonal antibody, MORAb-004, was engineered to target endosia...

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I publikationen:Clin Cancer Res
Huvudupphovsmän: Diaz, Luis A., Coughlin, Christina M., C.Weil, Susan, Fishel, Jean, Gounder, Mrinal M., Lawrence, Susan, Azad, Nilofer, O'Shannessy, Daniel J., Grasso, Luigi, Wustner, Jason, Ebel, Wolfgang, Carvajal, Richard D.
Materialtyp: Artigo
Språk:Inglês
Publicerad: 2014
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Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC4612616/
https://ncbi.nlm.nih.gov/pubmed/25398449
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-14-1829
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