Development of (89)Zr-Ontuxizumab for in vivo TEM-1/endosialin PET applications

PURPOSE: The complexity of sarcoma has led to the need for patient selection via in vivo biomarkers. Tumor endothelial marker-1 (TEM-1) is a cell surface marker expressed by the tumor microenvironment. Currently MORAb-004 (Ontuxizumab), an anti-TEM-1 humanized monoclonal antibody, is in sarcoma clin...

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Udgivet i:Oncotarget
Main Authors: Lange, Sara E.S., Zheleznyak, Alex, Studer, Matthew, O'Shannessy, Daniel J., Lapi, Suzanne E., Van Tine, Brian A.
Format: Artigo
Sprog:Inglês
Udgivet: Impact Journals LLC 2016
Fag:
Research Paper
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4914343/
https://ncbi.nlm.nih.gov/pubmed/26909615
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.7552
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