A Nanobody Binding to Non-Amyloidogenic Regions of the Protein Human Lysozyme Enhances Partial Unfolding but Inhibits Amyloid Fibril Formation

[Image: see text] We report the effects of the interaction of two camelid antibody fragments, generally called nanobodies, namely cAb-HuL5 and a stabilized and more aggregation-resistant variant cAb-HuL5G obtained by protein engineering, on the properties of two amyloidogenic variants of human lysoz...

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Detalhes bibliográficos
Publicado no:J Phys Chem B
Main Authors: De Genst, Erwin, Chan, Pak-Ho, Pardon, Els, Hsu, Shang-Te D., Kumita, Janet R., Christodoulou, John, Menzer, Linda, Chirgadze, Dimitri Y., Robinson, Carol V., Muyldermans, Serge, Matagne, André, Wyns, Lode, Dobson, Christopher M., Dumoulin, Mireille
Formato: Artigo
Idioma:Inglês
Publicado em: 2013
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4612432/
https://ncbi.nlm.nih.gov/pubmed/23919586
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jp403425z
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