Disease-related amyloidogenic variants of human lysozyme trigger the unfolded protein response and disturb eye development in Drosophila melanogaster

We have created a Drosophila model of lysozyme amyloidosis to investigate the in vivo behavior of disease-associated variants. To achieve this objective, wild-type (WT) protein and the amyloidogenic variants F57I and D67H were expressed in Drosophila melanogaster using the UAS-gal4 system and both t...

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Detalhes bibliográficos
Main Authors: Kumita, Janet R., Helmfors, Linda, Williams, Jocy, Luheshi, Leila M., Menzer, Linda, Dumoulin, Mireille, Lomas, David A., Crowther, Damian C., Dobson, Christopher M., Brorsson, Ann-Christin
Formato: Artigo
Idioma:Inglês
Publicado em: Federation of American Societies for Experimental Biology 2012
Assuntos:
Research Communications
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3250245/
https://ncbi.nlm.nih.gov/pubmed/21965601
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1096/fj.11-185983
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