Local Cooperativity in an Amyloidogenic State of Human Lysozyme Observed at Atomic Resolution

[Image: see text] The partial unfolding of human lysozyme underlies its conversion from the soluble state into amyloid fibrils observed in a fatal hereditary form of systemic amyloidosis. To understand the molecular origins of the disease, it is critical to characterize the structural and physicoche...

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Autori principali: Dhulesia, Anne, Cremades, Nunilo, Kumita, Janet R., Hsu, Shang-Te Danny, Mossuto, Maria F., Dumoulin, Mireille, Nietlispach, Daniel, Akke, Mikael, Salvatella, Xavier, Dobson, Christopher M.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Chemical Society 2010
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2974344/
https://ncbi.nlm.nih.gov/pubmed/20958028
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ja103524m
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