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Population of non-native states of lysozyme variants drives amyloid fibril formation

The propensity of protein molecules to self-assemble into highly ordered, fibrillar aggregates lies at the heart of the understanding of many disorders such as Alzheimer’s disease or lysozyme systemic amyloidosis. In this article we use highly accurate kinetic measurements of amyloid fibril growth i...

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Detalhes bibliográficos
Publicado no:J Am Chem Soc
Main Authors: Buell, Alexander K., Dhulesia, Anne, Mossuto, Maria F., Cremades, Nunilo, Kumita, Janet R., Dumoulin, Mireille, Welland, Mark E., Knowles, Tuomas P.J., Salvatella, Xavier, Dobson, Christopher M.
Formato: Artigo
Idioma:Inglês
Publicado em: 2011
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4982536/
https://ncbi.nlm.nih.gov/pubmed/21528861
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ja109620d
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