The Significance of the Location of Mutations for the Native-State Dynamics of Human Lysozyme

The conversion of human lysozyme into amyloid fibrils is associated with a rare but fatal hereditary form of nonneuropathic systemic amyloidosis. The accumulation of large amounts of aggregated protein is thought to be initiated by the formation of transient intermediate species of disease-related l...

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Udgivet i:Biophys J
Main Authors: Ahn, Minkoo, Hagan, Christine L., Bernardo-Gancedo, Ana, De Genst, Erwin, Newby, Francisco N., Christodoulou, John, Dhulesia, Anne, Dumoulin, Mireille, Robinson, Carol V., Dobson, Christopher M., Kumita, Janet R.
Format: Artigo
Sprog:Inglês
Udgivet: The Biophysical Society 2016
Fag:
Proteins
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5153563/
https://ncbi.nlm.nih.gov/pubmed/27926837
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bpj.2016.10.028
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