A non-natural variant of human lysozyme (I59T) mimics the in vitro behaviour of the I56T variant that is responsible for a form of familial amyloidosis

We report here the detailed characterisation of a non-naturally occurring variant of human lysozyme, I59T, which possesses a destabilising point mutation at the interface of the α- and β-domains. Although more stable in its native structure than the naturally occurring variants that give rise to a f...

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Bibliographische Detailangaben
Hauptverfasser: Hagan, Christine L., Johnson, Russell J.K., Dhulesia, Anne, Dumoulin, Mireille, Dumont, Janice, De Genst, Erwin, Christodoulou, John, Robinson, Carol V., Dobson, Christopher M., Kumita, Janet R.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Oxford University Press 2010
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Original Articles
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2920300/
https://ncbi.nlm.nih.gov/pubmed/20382744
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/protein/gzq023
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