Application of Lysine-specific Labeling to Detect Transient Interactions Present During Human Lysozyme Amyloid Fibril Formation

Populating transient and partially unfolded species is a crucial step in the formation and accumulation of amyloid fibrils formed from pathogenic variants of human lysozyme linked with a rare but fatal hereditary systemic amyloidosis. The partially unfolded species possess an unstructured β-domain a...

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Publicado no:Sci Rep
Main Authors: Ahn, Minkoo, Waudby, Christopher A., Bernardo-Gancedo, Ana, De Genst, Erwin, Dhulesia, Anne, Salvatella, Xavier, Christodoulou, John, Dobson, Christopher M., Kumita, Janet R.
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5670245/
https://ncbi.nlm.nih.gov/pubmed/29101328
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-14739-5
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