The Significance of the Location of Mutations for the Native-State Dynamics of Human Lysozyme

The conversion of human lysozyme into amyloid fibrils is associated with a rare but fatal hereditary form of nonneuropathic systemic amyloidosis. The accumulation of large amounts of aggregated protein is thought to be initiated by the formation of transient intermediate species of disease-related l...

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Bibliographische Detailangaben
Veröffentlicht in:Biophys J
Hauptverfasser: Ahn, Minkoo, Hagan, Christine L., Bernardo-Gancedo, Ana, De Genst, Erwin, Newby, Francisco N., Christodoulou, John, Dhulesia, Anne, Dumoulin, Mireille, Robinson, Carol V., Dobson, Christopher M., Kumita, Janet R.
Format: Artigo
Sprache:Inglês
Veröffentlicht: The Biophysical Society 2016
Schlagworte:
Proteins
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5153563/
https://ncbi.nlm.nih.gov/pubmed/27926837
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bpj.2016.10.028
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