The Significance of the Location of Mutations for the Native-State Dynamics of Human Lysozyme

The conversion of human lysozyme into amyloid fibrils is associated with a rare but fatal hereditary form of nonneuropathic systemic amyloidosis. The accumulation of large amounts of aggregated protein is thought to be initiated by the formation of transient intermediate species of disease-related l...

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Vydáno v:Biophys J
Hlavní autoři: Ahn, Minkoo, Hagan, Christine L., Bernardo-Gancedo, Ana, De Genst, Erwin, Newby, Francisco N., Christodoulou, John, Dhulesia, Anne, Dumoulin, Mireille, Robinson, Carol V., Dobson, Christopher M., Kumita, Janet R.
Médium: Artigo
Jazyk:Inglês
Vydáno: The Biophysical Society 2016
Témata:
Proteins
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5153563/
https://ncbi.nlm.nih.gov/pubmed/27926837
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bpj.2016.10.028
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