Atomic structure of a nanobody-trapped domain-swapped dimer of an amyloidogenic β2-microglobulin variant

Atomic-level structural investigation of the key conformational intermediates of amyloidogenesis remains a challenge. Here we demonstrate the utility of nanobodies to trap and characterize intermediates of β2-microglobulin (β2m) amyloidogenesis by X-ray crystallography. For this purpose, we selected...

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Detalhes bibliográficos
Main Authors: Domanska, Katarzyna, Vanderhaegen, Saskia, Srinivasan, Vasundara, Pardon, Els, Dupeux, Florine, Marquez, Jose A., Giorgetti, Sofia, Stoppini, Monica, Wyns, Lode, Bellotti, Vittorio, Steyaert, Jan
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2011
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3029709/
https://ncbi.nlm.nih.gov/pubmed/21220305
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1008560108
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