Atomic structure of a nanobody-trapped domain-swapped dimer of an amyloidogenic β2-microglobulin variant

Atomic-level structural investigation of the key conformational intermediates of amyloidogenesis remains a challenge. Here we demonstrate the utility of nanobodies to trap and characterize intermediates of β2-microglobulin (β2m) amyloidogenesis by X-ray crystallography. For this purpose, we selected...

Description complète

Enregistré dans:
Détails bibliographiques
Auteurs principaux: Domanska, Katarzyna, Vanderhaegen, Saskia, Srinivasan, Vasundara, Pardon, Els, Dupeux, Florine, Marquez, Jose A., Giorgetti, Sofia, Stoppini, Monica, Wyns, Lode, Bellotti, Vittorio, Steyaert, Jan
Format: Artigo
Langue:Inglês
Publié: National Academy of Sciences 2011
Sujets:
Biological Sciences
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3029709/
https://ncbi.nlm.nih.gov/pubmed/21220305
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1008560108
Tags: Ajouter un tag
Pas de tags, Soyez le premier à ajouter un tag!

Documents similaires